What potential health issues may arise from chronic exposure to inorganic arsenicals?

Chronic exposure to inorganic arsenicals is associated with significant health risks, most notably the potential for genetic defects and cancer. This is due to arsenic's toxicological properties, which can lead to cellular damage and alterations in DNA that may result in mutations over time. Such genetic changes can increase the risk of various cancers, including skin, bladder, and lung cancer, among others.

Additionally, arsenic exposure has been shown to interact with the body’s cellular mechanisms, potentially leading to disruptions in normal cellular repair processes. The resulting accumulation of damage can promote tumorigenesis, which is the formation of tumors. Consequently, the correlation between inorganic arsenicals and these severe long-term health effects is well-established in the field of environmental health and toxicology.

While the other options suggest possible health issues, they are not primarily linked to the long-term effects of inorganic arsenicals as strongly as genetic defects and cancer.